C. elegans screen uncovers targets to delay motor aging

Genome-wide screen in the nematode Caenorhabditis elegans reveals potential targets to delay motor aging, including the phosphatidylinositol 3-kinase VPS-34; genetic and pharmacological partial inhibition of VPS-34 improves neurotransmission and muscle integrity through increased PI(3)P-PI-PI(4)P conversion, ameliorating motor aging in both worms and mice.

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