Outcomes in Pediatric COVID-19 with Renal Involvement

NKF Spring Clinical Meetings 2021

There are few information accessible on the epidemiology of acute kidney harm (AKI), related danger elements, therapies, and mortality fee amongst pediatric patients with COVID-19 admitted to the intensive care unit (ICU). AKI is a typical and extreme complication in youngsters and adolescents with COVID-19, and an understanding of the illness will assist in improvement of therapy and preventative care methods to scale back morbidity and mortality in that affected person inhabitants.

Isabelle Mawby and colleagues performed a research to look at the incidence of AKI amongst COVID-19 sufferers in pediatric ICUs in North American utilizing the Virtual Pediatric Systems (VPS) database. The researchers additionally sought to evaluate COVID-19-related danger elements; therapies, together with kidney substitute remedy (KRT); and mortality charges. Results of the evaluation had been reported throughout a digital poster session on the NKF Spring Clinical Meetings 2021 in a poster titled Acute Kidney Injury in COVID-19 Pediatric Patients: Analysis of the Virtual Pediatric Systems Data.

The retrospective research included sufferers ≤24 years of age with COVID-19 in the VPS COVID-19 database who had been admitted to the ICU between January 1, 2020, and June 30, 2020. The poster reported outcomes of research of knowledge on 1240 pediatric sufferers with COVID-19.

Of the 1240 sufferers, 172 had renal/urinary system involvement. Of these 172, there have been 19 confirmed deaths, translating to 45% of all confirmed pediatric COVID-19 deaths related with renal involvement. Of the 36 sufferers who required KRT, two died. An further 264 (24.67%) sufferers had been recognized with MIS-C (multisystem inflammatory syndrome in youngsters).

In conclusion, the researchers mentioned, “Although COVID-19 in the pediatric inhabitants tends to current extra favorably, renal involvement among the many pediatric COVID-19 inhabitants could also be thought of a detrimental prognostic issue with respect to affected person outcomes.”

Source: Mawby I, Chakraborty R, Pandya A, Mahajan S, Raina R. Acute kidney harm in COVID-19 pediatric sufferers: Analysis of the digital pediatric system information. Abstract of a poster introduced on the digital National Kidney Foundation Spring Clinical Meetings 2021 (Poster #16), April 9, 2021.

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